Epstein-Barr Virus, Epigenetics, and Cancer
Welcome to the TEMPERA LAB
We are located in the Fels Institute for Cancer Research and Molecular Biology at the Lewis Katz School of Medicine – Temple University. We pursue two lines of research: one focus is on how chromatin can regulate the complex and dynamic gene expression patterns adopted by the oncovirus Epstein-Barr Virus (EBV) during persistence infection; a second focus is on an important family of polymerases, the poly-ADP ribose polymerases (PARPs), which regulate functions like DNA repair, genomic stability, and apoptosis.
We utilize our expertise in chromatin immunoprecipitation, Chromatin Conformation Capture (3C) assay, and genome-wide data analysis to better understand the link between three-dimensional structure of chromosome, chromatin composition and gene expression during EBV latency and PARP activation. We aim in the long run to identify new cellular functions regulated by EBV and PARP1 that can be targeted by epigenetic drugs and to provide novel therapeutic approaches for treating EBV+ cancer. Learn more
October 2018 Our paper describing the importance of PARP1 for LMP1-mediated gene expression has been accepted for publication at PLOS Pathogens. Congratulations to Michael for his work.
September 2018 It was great presenting our work at The 2018 Chromatin Control of Viral Infection
August 2018 The 2018 Chromatin Control of Viral Infection promises to be very informative with a lot of great talks, including one from our laboratory. On September 6, Italo will discuss our recent works showing how PARP1 activity regulates EBV chromatin.
July 2018 The Tempera Lab will attend the IHW 2018. There will be a talk from Michael Sunday 07/22 at 4:30, a poster presentation from Lisa during the poster session Monday 07/23 at 12:30, and a talk from Italo Tuesday 07/24 at 5:05.