Epstein-Barr Virus, Epigenetics, and Cancer

Welcome to the TEMPERA LAB

We are located in The Wistar Institute. We pursue two lines of research: one focus is on how chromatin can regulate the complex and dynamic gene expression patterns adopted by the oncovirus Epstein-Barr Virus (EBV) during persistence infection; a second focus is on an important family of polymerases, the poly-ADP ribose polymerases (PARPs), which regulate functions like DNA repair, genomic stability, and apoptosis.

We utilize our expertise in chromatin immunoprecipitation, Chromatin Conformation Capture (3C) assay, and genome-wide data analysis to better understand the link between the three-dimensional structure of the chromosome, chromatin composition, and gene expression during EBV latency and PARP activation. We aim in the long run to identify new cellular functions regulated by EBV and PARP1 that can be targeted by epigenetic drugs and to provide novel therapeutic approaches for treating EBV+ cancer. Learn more

The Latest

May 2020 The Tempera Lab has officially joined The Wistar Institute.

February 2020 The Tempera Lab will be joining The Wistar Institute this spring! Post doctoral positions will be available, soon.

January 2020 The Special Issue “Epigenetics and Viruses” in Viruses is open.

December 2019 Mike’s work on the role of LMP1 in regulating fatty acid metabolism during EBV infection is out in bioRxiv