Epstein-Barr Virus, Epigenetics, and Cancer
Welcome to the TEMPERA LAB
We are located in the Fels Institute for Cancer Research and Molecular Biology at the Lewis Katz School of Medicine – Temple University. We pursue two lines of research: one focus is on how chromatin can regulate the complex and dynamic gene expression patterns adopted by the oncovirus Epstein-Barr Virus (EBV) during persistence infection; a second focus is on an important family of polymerases, the poly-ADP ribose polymerases (PARPs), which regulate functions like DNA repair, genomic stability, and apoptosis.
We utilize our expertise in chromatin immunoprecipitation, Chromatin Conformation Capture (3C) assay, and genome-wide data analysis to better understand the link between three-dimensional structure of chromosome, chromatin composition and gene expression during EBV latency and PARP activation. We aim in the long run to identify new cellular functions regulated by EBV and PARP1 that can be targeted by epigenetic drugs and to provide novel therapeutic approaches for treating EBV+ cancer. Learn more
January 2020 The Special Issue “Epigenetics and Viruses” in Viruses is open.
December 2019 Mike’s work on the role of LMP1 in regulating fatty acid metabolism durint EBV infection is out in bioRxiv
November 2019 We have a Postdoctoral position available. Please check the job describtion that has been advertised in Science Careers website