Welcome to the TEMPERA LAB
We are located in The Wistar Institute. We pursue two lines of research: one focus is on how chromatin can regulate the complex and dynamic gene expression patterns adopted by the oncovirus Epstein-Barr Virus (EBV) during persistence infection; a second focus is on an important family of polymerases, the poly-ADP ribose polymerases (PARPs), which regulate functions like DNA repair, genomic stability, and apoptosis.
We utilize our expertise in chromatin immunoprecipitation, Chromatin Conformation Capture (3C) assay, and genome-wide data analysis to better understand the link between the three-dimensional structure of the chromosome, chromatin composition, and gene expression during EBV latency and PARP activation. We aim in the long run to identify new cellular functions regulated by EBV and PARP1 that can be targeted by epigenetic drugs and to provide novel therapeutic approaches for treating EBV+ cancer. Learn more